En-hedu-Ana was revered as the most important religious figure of her day.

She is the first author either gender known by name in human history, because she wrote the first texts that can be attributed to a person. 

She was the high-priestress during the reign of Sargon of Akkad (Sargon the Great). While Sargon of Akkad united Sumer and Akkad and conquered the first empire in history, Enheduanna melded the Sumerian with the Akkadian gods to create the stability the empire needed to thrive.

read here more about ......The Role of Women in Ancient Sumer 

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Puduhepa was a Hittite Queen, a Tawananna - married to King Hattusili III. She has been referred to as "one of the most influential women known from the Ancient Near East."

Queen Puduhepa and King Hatusilli III together with Pharaoh Ramses II, put their seal under the first international peace treaty in human history, between the great powers of Egypt and the Hittites. (Die Hethiter und ihr Reich, Wissenschaftliche Buch Gesellschaft, Germany - Page 71)

The "Minoans" were the first European high culture. The first European throne was found here. They lived among other in a kind of palaces, for example, the palace of Knossos with over 1400 rooms on 3-4 storeys. There was a even a central sewer system, toilets and a type of hot water heating, etc.

 
Their Scripture - Linear A - has not yet been deciphered. Many well-preserved frescoes have been found that give an insight into the culture. Almost all Images are of women. Women in the role of priestesses were in the important social functions.

Blenda is the heroine of a Swedish legend (Blendasägnen) from Småland. Blenda led the rural women of Värend in an attack on a pillaging Danish army and annihilated the invaders.

Hatshepsut  meaning Foremost of Noble Ladies was the fifth pharaoh of the Eighteenth dynasty of Ancient Egypt. She is generally regarded by Egyptologists as one of the most successful pharaohs, reigning longer than any other woman of an indigenous Egyptian dynasty.

According to Egyptologist James Henry Breasted she is also known as "the first great woman in history of whom we are informed."

Co-Regent of upper and lower Egipt together with Echnaton at the time of the biggest revolution in the ancient egypt   1370 BCE – ca. 1330 BCE

Nefertiti  was the Great Royal Wife of the Egyptian Pharaoh Akhenaten. Nefertiti and her husband were known for a religious revolution, in which they worshiped one god only, Aten, or the sun disc.

After Akhenaten death,  Nefertiti ruled briefly as Pharaoh Smenkhkare.

Nefertiti (Beauty of Aten, the Beautiful one has come) is best known by the bust in limestone and gypsum, which is exhibited in the Egyptian Museum in Berlin.  The name bears the title of Great Royal Wife and mistress of the Two Lands. 

In the grave of Akhenaten she appears as mistress of Upper and Lower Egypt.

After the death of Akhenaten Nefertiti rules as pharao Semenchkare.

Wencheng has brought Buddhism to Tibet, she is part of the foundation story of Tibet. 

Today she is revered as the white Tara, the female Buddha. 

Wencheng was the daughter of Emperor Taizong of the Tang Dynasty, she was married as a pledge of peace with Songstan Gampo the first Dharma King of Tibet.

Boudicca was a Queen and a Britannian army leader who in the early years of the Roman occupation led the Boudicca uprising and if they would have won, she would have changed the destiny of Europe.